Experimental Lathyrism

Changes in permeability of articular cartilage in experimental lathyrism.

Articular cartilage does not contain blood vessels, the nutrition of chrondrocytes being derived mainly by diffusion of synovial fluid (Stockwell and Barnett, 1964; Ekholm, 1951). It has been demonstrated that the permeability of articular cartilage diminishes with ageing (Stockwell and Barnett, 1964; Tsaltsas and Kyriazis, 1967). This change has been attributed not only to the physical changes...

Experimental Induction ofTumor-like Lesions

During the course of some investigations of ex perimental lathyrism in salamanders, we noted and reported that, if the eggs of the salamander Ambysioma punctatum were placed in solutions of the lathyrism factor, the larval forms exhibited tumors of the notochord (2) . Since that time, no reports have appeared concerning the production of experimental ehordomas in other animals. In our original ...

Periodontal & systemic bone changes in rats with experimental lathyrism.

BACKGROUND & OBJECTIVE It is not clear how lathyrism affects the systemic bone metabolism. We therefore undertook a study to observe periodontal and systemic bone changes by performing radiological, metabolic, and bone densitometric evaluations in rats with experimental lathyrism. METHODS A total of 30 rats were used. Experimental lathyrism was induced by once daily subcutaneous administratio...

El Niño-southern oscillations and lathyrism epidemics

Epidemics of lathyrism, a neurological syndrome of spastic paraparesis, have occurred during severe droughts in Europe, Asia, and Africa for millenia. Causation is linked to exposure to β-N-oxalyl-L-α,β-diaminopropionic acid (β-L-ODAP), a neurotoxin in Lathyrus sativus. Lathyrism shares neurological features with konzo, a syndrome of predominantly spastic paraparesis which occurs during drought...

EXPERIMENTAL LATHYRISM An Autoradiographic Study

In normal and lathyritic chick embryos bone collagen was synthesized primarily in the periosteum of the femurs, and was organized as radioactive spicules in these bones. Saline extraction of the lathyritic bones removed the radioactive spicules, although they eventually seemed to become non-extractable. Normal bone seemed to be unaffected by saline extraction. Marked variation in the degree of ...

Lathyrism